The primary cilium orchestrates chondrocyte mechanotransduction
نویسندگان
چکیده
منابع مشابه
Signaling through the Primary Cilium
The presence of single, non-motile "primary" cilia on the surface of epithelial cells has been well described since the 1960s. However, for decades these organelles were believed to be vestigial, with no remaining function, having lost their motility. It wasn't until 2003, with the discovery that proteins responsible for transport along the primary cilium are essential for hedgehog signaling in...
متن کاملMathematically Modeling Chondrocyte Orientation and division in Relation to Primary Cilium
Confocal microscopy images show that growth plate chondrocytes will tend to form columns after cellular division[2], and the primary cilium may be responsible for the migration of the cells[4][5]. These cells have the ability to move within the growth plate, possibly influenced by the environment, and the primary cilium may direct the orientation and positioning of the cell in response to the e...
متن کاملThe importance of a single primary cilium
The centrosome is the main microtubule-organizing center in animal cells, and helps to influence the morphology of the microtubule cytoskeleton in interphase and mitosis. The centrosome also templates the assembly of the primary cilium, and together they serve as a nexus of cell signaling that provide cells with diverse organization, motility, and sensory functions. The majority of cells in the...
متن کاملTrafficking to the primary cilium membrane
The primary cilium has been found to be associated with a number of cellular signaling pathways, such as vertebrate hedgehog signaling, and implicated in the pathogenesis of diseases affecting multiple organs, including the neural tube, kidney, and brain. The primary cilium is the site where a subset of the cell's membrane proteins is enriched. However, pathways that target and concentrate memb...
متن کاملPrimary Cilium-Dependent Signaling Mechanisms
Primary cilia are hair-like organelles and play crucial roles in vertebrate development, organogenesis, health, and many genetic disorders. A primary cilium is a mechano-sensory organelle that responds to mechanical stimuli in the micro-environment. A cilium is also a chemosensor that senses chemical signals surrounding a cell. The overall function of a cilium is therefore to act as a communica...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2012
ISSN: 1063-4584
DOI: 10.1016/j.joca.2012.02.399